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H3Africa multi-centre study of the prevalence and environmental and genetic determinants of type 2 diabetes in sub-Saharan Africa: study protocol

Year: 2016
Type: article
Study design: Study Protocol
Abstract: The burden and aetiology of type 2 diabetes (T2D) and its microvascular complications may be influenced by varying behavioural and lifestyle environments as well as by genetic susceptibility. These aspects of the epidemiology of T2D have not been reliably clarified in sub-Saharan Africa (SSA), highlighting the need for context-specific epidemiological studies with the statistical resolution to inform potential preventative and therapeutic strategies. Therefore, as part of the Human Heredity and Health in Africa (H3Africa) initiative, we designed a multi-site study comprising case collections and population-based surveys at 11 sites in eight countries across SSA. The goal is to recruit up to 6000 T2D participants and 6000 control participants. We will collect questionnaire data, biophysical measurements and biological samples for chronic disease traits, risk factors and genetic data on all study participants. Through integrating epidemiological and genomic techniques, the study provides a framework for assessing the burden, spectrum and environmental and genetic risk factors for T2D and its complications across SSA. With established mechanisms for fieldwork, data and sample collection and management, data-sharing and consent for re-approaching participants, the study will be a resource for future research studies, including longitudinal studies, prospective case ascertainment of incident disease and interventional studies.
DOI: 10.1017/gheg.2015.6
Authors: K. Ekoru, E. H. Young, C. Adebamowo, N. Balde, B. J. Hennig, P. Kaleebu, S. Kapiga, N. S. Levitt, M. Mayige, J. C. Mbanya, M. I. McCarthy, O. Nyan, M. Nyirenda, J. Oli, K. Ramaiya, L. Smeeth, E. Sobngwi, C. N. Rotimi, M. S. Sandhu, A. A. Motala
Institutions: University of Cambridge, Wellcome Sanger Institute, University of Maryland, Baltimore, Institute of Human Virology, Donka Hospital, Gamal Abdel Nasser University of Conakry, London School of Hygiene & Tropical Medicine, MRC Unit the Gambia, MRC/UVRI & LSHTM Uganda Research Unit, Uganda Virus Research Institute, Mwanza Intervention Trials Unit, University of Nigeria Teaching Hospital, National Institute for Medical Research, University of Cape Town, Université de Yaoundé I, Centre for Human Genetics, Churchill Hospital, University of Oxford, NIHR Oxford Biomedical Research Centre, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of the Gambia, Edward Francis Small Teaching Hospital, Malawi Epidemiology and Intervention Research Unit, Muhimbili University of Health and Allied Sciences, National Institutes of Health, National Human Genome Research Institute, University of KwaZulu-Natal
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $1,350
Funders: Wellcome Trust, National Institute for Health and Care Research, Islamic Development Bank, Inyuvesi Yakwazulu-Natali, Medical Research Council, NIHR Cambridge Biomedical Research Centre
Awards: Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa., Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa, G4839860845, G4878468429, G5503369614, G7129414704, Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers, G9000219595
OpenAlex ID: W2294079108
FWCI: 0.578
Cites: 23
Cited by: 22
Related to: 10