Physics-based computer simulation of the long-term effects of cardiac regenerative therapies
Year: 2016
Type: article
Abstract: In this paper, we describe the application of an integrated electromechanics-growth computational model to simulate the long term effects of cardiac regenerative therapies in a left ventricle (LV). The electromechanics-growth model couples biophysically detailed cellular-based laws that describe the short term events occurring in the excitation-contraction coupling process in the cardiomyocytes, to a phenomenological law that describes the long-term process of growth and remodeling in the cardiac tissue. Two clinically relevant phases depicting the progression and subsequent treatment of heart failure were simulated using this model. These phases are namely, (1) the long-term remodeling process induced by a myocardial infarction and (2) the long-term response following regeneration of the infarct. Our model predictions show that the abnormal myofiber strain values surrounding the infarct can drive the post-infarct LV hypertrophy, whereas a subsequent normalization of the myofiber strain after infarct regeneration can lead to a reduction in the LV size. These findings are consistent with some of the observations found in the experiments and clinical studies of cardiac regenerative therapies.
Source: TECHNOLOGY
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2294625489