Synergies of genes in Alzheimer's disease.
Year: 2013
Type: conference-paper
Abstract: Nowadays, Alzheimer’s disease (AD) is the most common form of dementia affecting more than 25 million individuals worldwide. AD is a complex progressive neurodegenerative disorder of the brain and the prevalence of Alzheimer’s disease is expected to rise over the next decades [1]. Due to its poligenic nature, unconventional strategies for elucidating the genetic mechanisms and genetic risk factors are necessary. The microarray technology has made possible the monitoring of hundreds of genes simultaneous. Most studies on analysis of microarray data are based on the identification of differentially expressed genes on which further analysis is performed. There are several approaches to identify differentially expressed genes as feature selection method. However, due to the AD’s polygenic nature, it is believed that AD is caused not by defect in a few genes, but rather by variations in a large number of genes and their complex interplay. Therefore, a systems-level approach can provide new insights into the interplay of genes and it is an effective alternative for analyzing this complex disease.
Institutions: Universidad de Sevilla, Universidad Pablo de Olavide
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2295388861