Work

From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes

Year: 2015

Type: preprint

Abstract: Analysis of mutations in thousands of cancer genomes has revealed many characteristic patterns of mutagenesis. The search for the molecular mechanisms underlying these mutational patterns has not only generated novel biological insight but also led to the development of new experimental strategies to study cell-to-cell variation and genome evolution. In this essay, we discuss recent progress in the study of mutational mechanisms with a particular emphasis on the analysis of mutagenesis at the single-cell level.

Source: Cold Spring Harbor Symposia on Quantitative Biology

DOI: 10.1101/sqb.2015.80.027623

Authors: Cheng-Zhong Zhang, David Pellman

Institutions: Broad Institute, Harvard University, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Howard Hughes Medical Institute

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funder: National Cancer Institute

Award: Polyploidy, Aneuploidy and Genome Stability