Ant Colony Optimisation for Exploring Logical Gene-Gene Associations in Genome Wide Association Studies.
Year: 2013
Type: conference-paper
Abstract: In this paper a search for the logical variants of gene-gene interactions in genome-wide association study (GWAS) data using ant colony optimisation is proposed. The method based on stochastic algorithms is tested on a large established database from the Wellcome Trust Case Control Consortium and is shown to discover logical operations between combinations of single nucleotide polymorphisms that can discriminate Type II diabetes. A variety of logical combinations are explored and the best discovered associations are found within reasonable computational time and are shown to be statistically significant
Authors: Emmanuel Sapin, Ed Keedwell, Timothy M. Frayling
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funder: Wellcome Trust
OpenAlex ID: W2296453923