Year: 2016
Type: review
Abstract: Prostate cancer (PCa) is the most common cancer among men in the U.S. African American (AA) men have a higher incidence and mortality rate compared to European American (EA) men, but the cause of PCa disparities is still unclear. Epidemiologic studies have shown that vitamin D deficiency is associated with advanced stage and higher tumor grade and mortality, while its association with overall PCa risk is inconsistent. Vitamin D deficiency is also more common in AAs than EAs, and the difference in serum vitamin D levels may help explain the PCa disparities. However, the role of vitamin D in aggressive PCa in AAs is not well explored. Studies demonstrated that the active form of vitamin D, 1,25-dihydroxyvitamin D, has anti-inflammatory effects by mediating immune-related gene expression in prostate tissue. Inflammation also plays an important role in PCa pathogenesis and progression, and expression of immune-related genes in PCa tissues differs significantly between AAs and EAs. Unfortunately, the evidence linking vitamin D and immune response in relation to PCa is still scarce. This relationship should be further explored at a genomic level in AA populations that are at high risk for vitamin D deficiency and fatal PCa.
Source: Frontiers in Immunology
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G2364036934, Biological and Environmental modifiers of Vitamin D3 and Prostate Cancer Risk, G2524343597, VITAMIN D LEVELS AND RELATED GENETIC POLYMORPHISMS, SUN EXPOSURE, SKIN COLOR, AND RISK OF AGGRESSIVE PROSTATE CANCER, G4119534169, SPORE in Prostate Cancer, G5850682332, Biological & Environmental Mediators of Vitamin D and Aggressive Prostate Cancer, G6881605418, 3/3: The Chicago Cancer HealthEquity Collaborative (ChicagoCHEC), The Robert H. Lurie Comprehensive Cancer Center
OpenAlex ID: W2296605222