Year: 2016
Type: data-paper
Abstract: The Suppressor of Clear, Caenorhabditis elegans Homolog (SHOC2) is a scaffold protein that positively modulates activity of the RAS/ERK1/2 MAP kinase signaling cascade. We set out to understand the ERK1/2 pathway transcriptional response transduced through the SHOC2 scaffolding module. This data article describes raw gene expression within triplicates of kidney fibroblast-like Cos1 cell line expressing non-targeting shRNA (Cos-NT) and triplicates of Cos1 cells depleted of SHOC2 using shRNA (Cos-LV1) upon activation of ERK1/2 pathway by the Epidermal Growth Factor Receptor (EGFR). The data referred here is available in NCBI׳s Gene Expression Omnibus (GEO), accession GEO: GSE67063 as well as NCBI׳s Sequence Read Archive (SRA), accession SRA: SRP056324. A complete analysis of the results can be found in "Shoc2-tranduced ERK1/2 motility signals - Novel insights from functional genomics"(Jeoung et al., 2016) [1].
Source: Data in Brief
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,220
Funders: American Cancer Society, Center for Outcomes Research and Evaluation, Yale School of Medicine, University of Kentucky, National Institutes of Health, Office of the Vice President for Research, University of South Carolina, National Cancer Institute, National Institute of General Medical Sciences, National Center for Research Resources
Awards: Deciphering the molecular mechanisms underlying active scaffolding, Center for Biomedical Research Excellence in the Molecular Basis of Human Disease, Center for Biomedical Research Excellence in the Molecular Basis of Human Disease, G4836879385, Regulation of MAPK Activity by EGFR Endocytosis, G8240978563, University of Kentucky Markey Cancer Center – Cancer Center Support Grant, G9000261829, IDeA Networks of Biomedical Research Excellence in Kentucky
OpenAlex ID: W2298042651