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A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality

Year: 2010

Type: article

Study design: Observational Study

Abstract: Variation in personality traits is 30% to 60% attributed to genetic influences. Attempts to unravel these genetic influences at the molecular level have, so far, been inconclusive. We performed the first genome-wide association study of Cloninger’s temperament scales in a sample of 5117 individuals, in order to identify common genetic variants underlying variation in personality. Participants’ scores on Harm Avoidance, Novelty Seeking, Reward Dependence, and Persistence were tested for association with 1,252,387 genetic markers. We also performed gene-based association tests and biological pathway analyses. No genetic variants that significantly contribute to personality variation were identified, while our sample provides over 90% power to detect variants that explain only 1% of the trait variance. This indicates that individual common genetic variants of this size or greater do not contribute to personality trait variation, which has important implications regarding the genetic architecture of personality and the evolutionary mechanisms by which heritable variation is maintained.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/32ka-fs08

Authors: Karin J. H. Verweij, Brendan P. Zietsch, Sarah E. Medland, Scott D. Gordon, Beben Benyamin, Dale R. Nyholt, Brian P. McEvoy, Patrick F. Sullivan, Andrew C. Heath, P.A. Madden, Anjali K. Henders, Grant W. Montgomery, Nicholas G. Martin, Naomi R. Wray

Institutions: QIMR Berghofer Medical Research Institute, The University of Queensland, University of North Carolina at Chapel Hill, Washington University in St. Louis

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health

Awards: G1151563582, G16286648, Validation and Replication of Genes Associated with Common Human Disease Using Australian Twin Families, Molecular Epidemiology of Alcoholism 3 - EDAC Families, G3199409182, Identification of genetic risk factors for asthma: genome-wide association and the role of epigenetics, Genome-wide combined linkage-association scan of multiply phenotyped twin sibships, Pigmentation genes and melanoma risk, Genetics and prediction of complex disease risk, Association Screen of Migraine Candidate Genes, Towards an understanding of the causes of comorbidity of psychiatric disorders, Mapping Genes for typical migraine using twin families., Genetics of moliness, Develop & improve methodology in gene mapping, targetting localisation of genes underlying migraine & other disorders, Uncoupled Research Fellowship, Genetics of moliness, Molecular Epidemiology of Alcoholism 2- Big Sibships, VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION, Genetic Epidemiology of Pathological Gambling, PERSISTENCE AND CHANGE IN DRINKING HABITS--TWIN STUDY, Statistical Methods and Algorithms for Analysis of High-throughput Genetics and Genomics Platforms

OpenAlex ID: W2299151917

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