Work

A noninvasive examination for the diagnosis of pulmonary alveolar proteinosis: induced sputum in conjunction with transmission electron microscopy.

Year: 2014

Type: article

Abstract: Transmission electron microscopy (TEM) of sputum deposition (SD) is an important method to assist in the diagnosis of pulmonary alveolar proteinosis (PAP). However, the low positive rate and poor quality of slices restrict the application of sputum samples in the diagnosis of PAP. Furthermore, it can be more difficult to obtain a sufficient amount of sample for TEM if the patients have little or no sputum. In this paper, we successfully diagnosed a patient with PAP using induced sputum deposition (ISD) with TEM, which is a novel and noninvasive method for PAP diagnosis. Therefore, ISD combined with TEM can be an effective method for PAP diagnosis, especially when a lung biopsy and bronchoalveolar lavage (BAL) cannot be performed, or little or no sputum can be obtained.

Source: Europe PMC (PubMed Central)

Authors: Pan Gu, Xia Fang, Benfang Luo, Hanzhang Chen, Yu Zeng, Hanjing Lv, Lanjing Zhang, Xianghua Yi

Institutions: Tongji University, Shanghai Pulmonary Hospital, Rutgers, The State University of New Jersey, University Medical Center of Princeton, Rutgers Cancer Institute

Language: English

Topic: Medical Imaging and Pathology Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2299194401

FWCI: 0.267

Cites: 12

Cited by: 2

Related to: 10