Work

The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors

Year: 2016

Type: article

Abstract: The β-arrestins (βarrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse array of cellular functions. To signal in such a complex fashion, βarrs adopt multiple conformations and are regulated at multiple levels to differentially activate downstream pathways. Recent structural studies have demonstrated that βarrs have a conserved structure and activation mechanism, with plasticity of their structural fold, allowing them to adopt a wide array of conformations. Novel roles for βarrs continue to be identified, demonstrating the importance of these dynamic regulators of cellular signaling.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r115.713313

Authors: Jeffrey S. Smith, Sudarshan Rajagopal

Institutions: Duke Medical Center, Duke University

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: Burroughs Wellcome Fund, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences