Year: 2015
Type: article
Study design: Observational Study
Abstract: Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence brain morphology. Here, we examine brain imaging and single-nucleotide polymorphisms (SNPs) data from ∼2,700 individuals. We show that a substantial proportion of variation in cortical surface area is explained by additive effects of SNPs dispersed throughout the genome, with a larger heritable effect for visual and auditory sensory and insular cortices (h(2)∼0.45). Genome-wide SNPs collectively account for, on average, about half of twin heritability across cortical regions (N=466 twins). We find enriched genetic effects in or near genes. We also observe that SNPs in evolutionarily more conserved regions contributed significantly to the heritability of cortical surface area, particularly, for medial and temporal cortical regions. SNPs in less conserved regions contributed more to occipital and dorsolateral prefrontal cortices.
Source: Nature Communications
DOI: 10.1038/ncomms8549
Authors: Chi-Hua Chen, Qian Peng, Andrew J. Schork, Min-Tzu Lo, Chun-Chieh Fan, Yunpeng Wang, Rahul S. Desikan, Francesco Bettella, Donald J. Hagler, Pediatric Imaging, Neurocognition and Genetics Study, Connor McCabe, Linda Chang, Natacha Akshoomoff, Erik Newman, Thomas Ernst, Peter Van Zijl, Joshua Kuperman, Sarah Murray, Cinnamon Bloss, Mark Appelbaum, Anthony Gamst, Wesley Thompson, Hauke Bartsch, Alzheimer’s Disease Neuroimaging Initiative, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack Jr, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulman, William Potter, Peter J. Snyder, Adam Schwartz, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles DeCarli, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Robert A. Koeppe, Norm Foster, Eric M. Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel J. Cairns, Erin Householder, Lisa Taylor-Reinwald, Virginia M.Y. Lee, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Tatiana M. Foroud, Steven Potkin, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Leon Thal, Richard Frank, Neil Buckholtz, Marilyn Albert, John Hsiao, Lars T. Westlye, William S. Kremen, Terry L. Jernigan, Stephanie Le Hellard, Vidar M. Steen, Thomas Espeseth, Matt Huentelman, Asta K. Håberg, Ingrid Agartz, Srdjan Djurovic, Ole A. Andreassen, Nicholas Schork, Anders M. Dale
Institutions: University of California San Diego, Scripps Research Institute, J. Craig Venter Institute, University of Oslo, Kennedy Krieger Institute, University of Hawaii System, University of California, San Francisco, Mayo Clinic, University of California, Berkeley, University of Pennsylvania, University of Southern California, University of California, Davis, Brigham and Women's Hospital, Harvard University, Indiana University Indianapolis, Washington University in St. Louis, Prevent Alzheimer’s Disease 2020, Siemens (Germany), Alzheimer's Association, University of Pittsburgh, Cornell University, Albert Einstein College of Medicine, Yeshiva University, Alzheimer's Drug Discovery Foundation, Acumen Pharmaceuticals (United States), Northwestern University, National Institute of Mental Health, Brown University, Eli Lilly (United States), University of Washington, University of London, University of Michigan, University of Utah, Banner Alzheimer’s Institute, University of California, Irvine, General Electric (United States), National Institutes of Health, National Institute on Aging, Johns Hopkins University, Oslo University Hospital, Center of Excellence for Stress and Mental Health, University of Bergen, Haukeland University Hospital, Translational Genomics Research Institute, St Olav's University Hospital, Diakonhjemmet Hospital, Norwegian University of Science and Technology
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
Funders: U.S. Department of Defense, Foundation for the National Institutes of Health, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, Biogen, University of Southern California, F. Hoffmann-La Roche, Medpace, Meso Scale Diagnostics, Synarc, Alzheimer's Disease Neuroimaging Initiative, BioClinica, Novartis Pharmaceuticals Corporation, Norges Teknisk-Naturvitenskapelige Universitet, National Alliance for Research on Schizophrenia and Depression, Northern California Institute for Research and Education, European Commission, Eisai, Helse Midt-Norge, Norges Forskningsråd, Servier, IXICO, National Institutes of Health, Genentech, University of California, San Diego, Canadian Institutes of Health Research, National Institute on Aging, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Biomedical Imaging and Bioengineering
Awards: G100845555, G1012222616, G104586243, G1146727800, G1554142629, G1593117279, G1650819308, G1751636013, G1823308732, Alzheimer's Disease Neuroimaging Initiative, G2100670906, G2105457377, G2152643862, G2189010064, G2340207221, G2409989180, G2423387114, Creating a Pediatric Imaging-Genomics Data Resource, G2522063444, G2835601961, G2984240957, G29951154, G3130427885, G3131374986, G3146424788, IMAging GEnetics for MENtal Disorders, G3216574877, G3277956970, G3429535365, G3433676821, G3512028809, G3553156159, G3705772492, G3710456697, G3751924189, G3752451908, G3870774570, G3908963977, G3926333944, G3966393351, G3981823735, G4119534169, G43180419, G4401988282, G4475667458, G4501223628, G4800177743, G4860885537, G5207404921, G5209990037, G528601746, G5324093878, G5365730499, EFFECTS OF TRAUMATIC BRAIN INJURY (TBI) AND POST TRAUMATIC STRESS DISORDER (PTSD) ON ALZHEIMER'S DISEASE (AD) IN VETERANS USING IMAGING AND BIOMARKERS IN THE AD NEUROIMAGING INITIATIVE (ADNI)", G5389965057, The VETSA Longitudinal MRI Twin Study of Aging, G5654639750, G5740349702, G5760312152, G5850682332, G613619302, G6173816828, G6210868510, G6371410416, G6412110892, G6447063303, Identifying the Polygenic Basis of the Human Brain and Psychiatric Disorders, G6719828067, G6792506723, G6899163935, G6948409098, G72415811, G7298697282, G7385040984, G7414321945, The VETSA Longitudinal Twin Study of Cognition and Aging, G764699806, G7799614282, G781725486, G8228018387, G8270261256, G8281378126, G839208290, G8636843673, The VETSA longitudinal twin study of cognition and aging, G8852128998, G8895907669, G8897063270, G8957659042, G8973839845, G9000039018, G9000074849, G9000122335, Longevity Consortium, G920654007
OpenAlex ID: W1643374004