Work

Protein-protein interaction network : management of databases and its applications on the computational study of protein-protein interactions

Year: 2015

Type: dissertation

Abstract: The use of protein-protein interaction networks has become crucial due to the emergence of systems biology. The completeness and quality of networks, crucial to understand the biochemical mechanisms underlying a system such as a cell, are still challenging the scientific community. This thesis focuses on the data completeness challenge by the development of flexible tools for biological data management. It presents a database framework, BIANA, in which the integrated access to several information sources tackles this problem by unraveling hidden biological associations. BIANA is used to develop protein-protein interaction inference tools based on sequence similarity and protein-protein interactions. I have applied the approach on Salmonella-host infection, a case study where experimental data is scarce. Finally, I have focused on the integration problem of protein sequence annotation, also addressing the prediction of protein-protein interaction interfaces. I have developed a new evaluation measure to compare the predictive power of interface inference approaches.

Source: LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Author: Javier Garcı́a-Garcı́a

Language: English

Topic: Bioinformatics and Genomic Networks

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: European Commission, Bundesministerium für Bildung und Forschung, Generalitat de Catalunya, Ministerio de Ciencia e Innovación, Agència de Gestió d'Ajuts Universitaris i de Recerca

Award: Integrating bioinformatics and chemoinformatics approaches for the development of expert systems allowing the in silico prediction of toxicities

OpenAlex ID: W2300523755

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