Validity of Self-Reported CD4+ Count Among HIV-Infected Persons in Care
Year: 2015
Type: article
Study design: Observational Study
Abstract: Background. Data on the validity of self-reported CD4+ counts in outpatient settings are limited. Validity of self-report would support its use as a quick, non-invasive, and affordable data source for research and clinical care. Methods. We conducted an observational study at the Vanderbilt Comprehensive Care Clinic (Nashville, TN) from August 2012 to March 2015. Patients with self-reported CD4+ data were included. Demographic and laboratory data were abstracted from medical records. CD4+ knowledge was a self-report value within 50 cells/μL of the immediate prior actual value. Relationship between self-reported and actual values was assessed by Spearman's rank correlation. Odds ratios (OR) for lack of CD4+ knowledge were estimated by logistic regression. Results. There were 74 persons included; median age was 43, 72% were male, 57% were black. Median actual CD4+ count was 609 cells/μL (interquartile range [IQR]: 323-828). Median lag from actual to self-report value was 91 days (IQR: 18-126). Persons with CD4+ knowledge were similar to those without such knowledge regarding age, sex, race, injection drug use (IDU) as HIV risk factor, high school education/equivalent, actual CD4+ count, and year of enrollment in care. Of those able to recall a CD4 + value (n = 41, 55%), 33 (80%) had CD4+ knowledge. There was a 0.97 (p < 0.001) correlation between self-reported and actual values. In adjusted analysis, black race and lag between self-reported and actual values were independently associated with lack of CD4+ knowledge (table). Conclusion. In our study, self-reported CD4+ was correlated with the value obtained by chart review. These findings support the use of self-reported CD4+ counts for clinical care and research purposes when other methods are not available. Further study is needed to examine potential unmeasured confounders such as health literacy and numeracy. Disclosures. All authors: No reported disclosures.
Source: Open Forum Infectious Diseases
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W2301099643