Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature
Year: 2015
Type: article
Abstract: BACKGROUND: Diurnal variation in blood pressure (BP) is regulated, in part, by an endogenous circadian clock; however, few human studies have identified associations between clock genes and BP. Accounting for environmental temperature may be necessary to correct for seasonal bias. METHODS: We examined whether environmental temperature on the day of participants' assessment was associated with BP, using adjusted linear regression models in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) (n = 819) and the Boston Puerto Rican Health Study (BPRHS) (n = 1,248) cohorts. We estimated phenotypic variance in BP by 18 clock genes and examined individual single-nucleotide polymorphism (SNP) associations with BP using an additive genetic model, with further consideration of environmental temperature. RESULTS: In GOLDN, each additional 1 °C increase in environmental temperature was associated with 0.18 mm Hg lower systolic BP [SBP; β ± SE = -0.18 ± 0.05 mm Hg; P = 0.0001] and 0.10mm Hg lower diastolic BP [DBP; -0.10 ± 0.03 mm Hg; P = 0.001]. Similar results were seen in the BPRHS for SBP only. Clock genes explained a statistically significant proportion of the variance in SBP [V G/V P ± SE = 0.071 ± 0.03; P = 0.001] in GOLDN, but not in the BPRHS, and we did not observe associations between individual SNPs and BP. Environmental temperature did not influence the identified genetic associations. CONCLUSIONS: We identified clock genes that explained a statistically significant proportion of the phenotypic variance in SBP, supporting the importance of the circadian pathway underlying cardiac physiology. Although temperature was associated with BP, it did not affect results with genetic markers in either study. Therefore, it does not appear that temperature measures are necessary for interpreting associations between clock genes and BP. CLINICAL TRIAL REGISTRATION: Trials related to this study were registered at clinicaltrials.gov as NCT00083369 (Genetic and Environmental Determinants of Triglycerides) and NCT01231958 (Boston Puerto Rican Health Study).
Source: American Journal of Hypertension
DOI: 10.1093/ajh/hpv082
Institutions: Tufts University, United States Department of Agriculture, Jean Mayer Human Nutrition Research Center on Aging, University of Alabama at Birmingham, Brigham and Women's Hospital, Harvard University, University of Massachusetts Lowell, Spanish National Centre for Cardiovascular Research, IMDEA Food
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,814
Awards: G1929859193, G313509969, Genetic and Environmental Determinants of Triglycerides, Mechanisms underlying adverse health consequences of shift work, Center for Research/Nutrition & Health among the Elderly, G609820727, Genetic predictors of metabolic responses to dairy, Genomewide Association Study of Lipid Response to Fenofibrate and Dietary Fat, Boston Puerto Rican Health Study - CVD Risk Factors, G803791895, PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH, G8813113705, G9000215657, G973459597, G984894956
OpenAlex ID: W2302272062