Work

Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer

Year: 2015

Type: article

Abstract: Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2015.1023928

Authors: Katherine L Cook, Jessica L Schwartz-Roberts, William T Baumann, Robert Clarke

Institutions: Georgetown University Medical Center, Georgetown Lombardi Comprehensive Cancer Center, Wake Forest University, Virginia Tech

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute