Work

Biochemistry of the sphingolipids: XII. conversion of cerebrosides to ceramides and sphingosine; structure of Gaucher cerebroside

Year: 1961

Type: article

Abstract: An improved procedure for the conversion of cerebroside to ceramide and sphingosine has been devised, consisting of periodate opening of the glycosidic ring, reduction with NaBH4, and hydrolysis under very mild acid conditions to ceramide. The over-all yield is excellent and only the erythro isomer results. Alkaline hydrolysis of ceramide gives erythro-sphingosine in good yield. Application of this procedure to Gaucher cerebroside has shown it to contain the “normal” erythro-sphingosine.

Source: Journal of Lipid Research

DOI: 10.1016/s0022-2275(20)39009-x

Authors: H.E. Carter, J.A. Rothfus, Roy Gigg

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W2302680933

FWCI: 0.933

Cites: 22

Cited by: 172

Related to: 10