Predicting the progression of Alzheimer's disease dementia: A multidomain health policy model
Year: 2016
Type: article
Abstract: INTRODUCTION: We develop a multidomain model to predict progression of Alzheimer's disease dementia (AD). METHODS: Data from the US National Alzheimer's Coordinating Center (n = 3009) are used to examine change in symptom status and to estimate transition probabilities between health states described using cognitive function, functional ability, and behavior. A model is used to predict progression and to assess a hypothetical treatment scenario that slows mild to moderate AD progression. RESULTS: More than 70% of participants moved state over 12 months. The majority moved in domains other than cognitive function. Over 5 years, of those alive more than half are in severe AD health states. Assessing an intervention scenario, we see fewer years in more severe health states and a potential impact (life years saved) due to mortality improvements. DISCUSSION: The model developed is exploratory and has limitations but illustrates the importance of using a multidomain approach when assessing impacts of AD and interventions.
Source: Alzheimer s & Dementia
Authors: Colin Green, Shenqiu Zhang
Institution: University of Exeter
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
Awards: G1173778324, UC Davis Alzheimer's Disease Core Center, Indiana Alzheimer Disease Center, Neurobiology of Alzheimer's Disease and Aging, Alzheimer's Disease Research Center, National Alzheimer's Coordinating Center, UCSD Alzheimer's Disease Research Center P50, Alzheimer's Disease Research Center, G3632542342, G384347443, G3919444319, G3946457848, G413369726, Alzheimer's Disease Core Center, The Alzheimer's Disease Research Center at the University of California, Irvine, Oregon Alzheimer's Disease Center, G556672640, Alzheimer's Disease Core Center, G5977822913, G611802359, Alzheimer's Disease Research Center - Overall, Wisconsin Alzheimer's Disease Research Center, University of Kansas Alzheimer's Disease Core Centers, Alzheimer's Disease Research Center, Alzheimer Disease Research Center, Arizona Alzheimer's Disease Core Center, Johns Hopkins Alzheimer's Disease Research Center, Boston University Alzheimer's Disease Center, Alzheimer's Disease Research Center, Alzheimer's Disease Core Center, Emory Alzheimer's Disease Center, G828200374, G9000030076, G9000132673, New Approaches to Dementia Heterogeneity, Mayo Alzheimer's Disease Research Center
OpenAlex ID: W2303510904