Work

Emerging model in anesthetic developmental neurotoxicity: human stem cells.

Year: 2013

Type: article

Abstract: R during the brain growth spurt period triggers neuroapoptosis. For instance, withdrawal of ketamine induced the compensatory upregulation of NMDAR expression followed by a toxic influx of calcium into neurons, leading to the elevated reactive oxygen species (ROS) generation and neuronal cell death. Administration of the antisense of NMDAR1 attenuated the ketamine-induced neuronal death [

Source: PubMed

Authors: Xiaowen Bai, Zeljko J Bosnjak

Institution: Medical College of Wisconsin

Language: English

Topic: Anesthesia and Neurotoxicity Research

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: MECHANISMS OF ANESTHETIC CARDIOPROTECTION, Anesthetics and Cardiac Signal Transduction