Increased homeostasis model assessment insulin resistance is a significant risk factor for colorectal adenoma in Japanese males
Year: 2011
Type: dissertation
Study design: Observational Study
Abstract: Many previous reports have documented a relationship between metabolic syndrome, in terms of insulin resistance, and colorectal cancer.However, the association of insulin resistance with colorectal adenoma has not been investigated in detail.To elucidate the association of metabolic syndrome components and insulin resistance with adenoma, homeostasis model assessment insulin resistance (HOMA-IR) and metabolic syndrome were investigated in individuals with adenoma.A cross-sectional study was conducted involving individuals who underwent scheduled health examinations using total colonoscopy.Total 963 males and 306 females were investigated.Male and female subjects comprised controls 702 and 260, individuals with adenoma 261 and 46, respectively.HOMA-IR was categorized into three groups as follows; normal (<1.6), intermediate (>1.6 -<2.5), and insulin resistance (≥2.5).Metabolic syndrome was defined by a combination of any three of the following components: central obesity (waist circumference >90 cm in men, 80 cm in women); elevated blood pressure (systolic blood pressure >130 mmHg and/or diastolic blood pressure >85 mmHg); elevated fasting plasma glucose (>100 mg/dL); reduced high-density lipoprotein-cholesterol (<40 mg/dL in men, <50 mg/dL in women); elevated triglyceride (>150 mg/dL).Only in male subjects, multivariate analysis of HOMA-IR showed that the intermediate and insulin resistance groups had a significantly increased risk for colorectal adenoma, even after adjustment for waist circumference (odds ratio, 1.62 and 2.23; 95% confidence interval, 1.07-2.45and 1.31-3.79,respectively).Accumulation of any metabolic syndrome components increased the risk of colorectal adenoma (P-trend =0.001).However, none of the components alone demonstrated a significant risk for colorectal adenoma.In female, no any significant risk was detected except component of triglyceride under the condition that evaluated by multivariate analysis.Our data indicate that an increased level of HOMA-IR is a significant risk factor for colorectal adenoma in Japanese males, surpassing any individual component of metabolic syndrome.
Author: 剛司 佐藤
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2306340249