Work

Macrophage multinucleation is accompanied by the expression of new soluble and membrane antigens in mice.

Year: 1989

Type: article

Abstract: Polyclonal antibodies were raised against mouse multinucleated giant cells to identify proteins specifically associated with multinucleated macrophages. A 115 kd membrane protein and a 160 kd soluble protein were detected by immunoprecipitation of radiolabeled giant cells and were not seen in mononucleated macrophages. This study demonstrated that giant cells express de novo synthesized proteins that are not present in macrophages and identified a new immunization technique to generate antibodies directed against cell surface components.

Source: Europe PMC (PubMed Central)

Author: A Vignery

Institution: Yale University

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health

Award: OSTEOCLASTS AND GIANT CELLS: MECHANISMS AND FUNCTIONS