Work

The preparation of metal–organic frameworks and their biomedical application

Year: 2016

Type: article

Abstract: The development of a safe and targetable drug carrier is a major challenge. An efficient delivery system should protect cargo from degradation and cleanup, and control of drug release in the target site. Metal-organic frameworks (MOFs), consisting of metal ions and a variety of organic ligands, have been applied for drug delivery due to their distinct structure. In this review, we summarized the synthesis strategies of MOFs, especially emphasizing the methods of pore creation in frameworks, which were based on recent literatures. Subsequently, the controlled size, biocompatibility, drug releasing performances, and imaging of MOFs were discussed, which would pave the road for the application in drug-delivery systems.

Source: International Journal of Nanomedicine

DOI: 10.2147/ijn.s100877

Authors: Rong Liu, Tian Yu, Zheng Shi, Zhiyong Wang

Institutions: Chengdu University, Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology

Language: English

Topic: Metal-Organic Frameworks: Synthesis and Applications

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836