Work

1041Economic Burden Associated with Key Gram-negative Pathogens among Patients with Complicated Urinary Tract Infections across US Hospitals

Year: 2014

Type: conference-abstract

Abstract: Background. cUTI is a frequent cause of hospitalization and results in considerable morbidity and mortality. While this is well appreciated, scant data are available on the economic burden posed by the various Gram-negative pathogens that cause cUTIs. The objectives of this study were to compare hospital length of stay (LOS) and total hospital costs for patients with cUTI due to different Gram-negative bacteria. Methods. Retrospective observational study using Premier research database was conducted. Inclusion criteria: (1) age ≥ 18 years, (2) patients with an admission to hospital for > 2 days between July 2012-June 2013, (3) primary diagnosis of cUTI by ICD-9 codes (590.1, 590.80, 590.8, and 599.0), (4) ICD-9 code for E. coli (041.4), K. pneumoniae (041.3), or Pseudomonas (041.7), and (5) received intravenous antibiotic within 3 days of hospital admission. Demographics, comorbid conditions, and outcomes were compared between pathogens of interests. Results. During the study period, 20688 hospitalized patients had a primary diagnosis of a cUTI across 487 hospitals and met the above criteria. Patient characteristics and outcomes are presented in the table. Conclusion. Economic burden associated with complicated urinary tract infection is substantial, especially for patients infected with gram negative infections. In our study, cUTI due to Pseudomonas and > 1 Gram-negative pathogen pose greater economic challenges underscoring the need for new agents to treat these increasingly difficult infections. Disclosures. M. Mocarski, Forest Research Institute: Employee, Salary Q. Zhao, Forest Research Institute: Employee, Salary M. Ding, Forest Research Institute: Employee, Salary S. Dixit, Forest Research Institute: Employee, Salary T. Lodise, Forest Research Institute: Consultant, Consulting fee

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofu052.749

Authors: Michelle Mocarski, Qi Zhao, Minming Ding, Shailja Dixit, Thomas Lodise

Institutions: Forest Laboratories (United States), Albany College of Pharmacy and Health Sciences

Language: English

Topic: Urinary Tract Infections Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053