Year: 2016
Type: review
Abstract: Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in diverse biological processes, including different aspects of immune functions. Ubiquitination regulates pattern-recognition receptor signaling that mediates both innate immune responses and dendritic cell maturation required for initiation of adaptive immune responses. Ubiquitination also regulates the development, activation, and differentiation of T cells, thereby maintaining efficient adaptive immune responses to pathogens and immunological tolerance to self-tissues. Like phosphorylation, ubiquitination is a reversible reaction tightly controlled by the opposing actions of ubiquitin ligases and deubiquitinases. Deregulated ubiquitination events are associated with immunological disorders, including autoimmune and inflammatory diseases.
Source: Cell Research
DOI: 10.1038/cr.2016.40
Authors: Hongbo Hu, Shao-Cong Sun
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Awards: G1012634304, Role of TBK1 in Regulating Dendritic Cell Function and Antitumor Immunity., Molecular mechanisms regulating TLR signaling and inflammation, Regulation of T-cell function and autoimmune inflammation by deubiquitinases., Regulation of T-cell function and autoimmune inflammation by deubiquitinase CYLD, Signaling functions of Peli family of E3 ubiquitin ligases, Molecular Studies of Noncanonical NF-kb Signaling, Regulation of MDM2-Mediated Oncogenesis and Anti-Tumor Immunity by USP15, G9000040331
OpenAlex ID: W2309366384