Work

The incubation period of Alzheimer’s disease and the timing of tau versus amyloid misfolding and spreading within the brain

Year: 2016

Type: article

Abstract: Having spent most of my career studying viral infections and their clinical manifestations, in particular AIDS, I have developed a keen interest in the incubation of diseases. In recent years I have focused my attention on Alzheimer’s disease (AD), so for me the key question concerning this illness is: when does AD start to develop? AD is tentatively diagnosed on the basis of a set of clinical symptoms (progressive irreversible decline in memory and other cognitive functions) and confirmed by neuropathology (brain atrophy accompanied by the accumulation of abundant extracellular amyloid β plaques and intraneuronal neurofibrillary tau lesions) [1] (Fig. 1a).

Source: European Journal of Epidemiology

DOI: 10.1007/s10654-016-0144-8

Author: Jaap Goudsmit

Institutions: Amsterdam UMC Location University of Amsterdam, Janssen (Netherlands), University of Amsterdam

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,690