Work

Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases

Year: 2016

Type: article

Abstract: Here, we report twoEnterobacter cloacaesequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. TheblaNDM-1-harboring plasmids carry IncA/C2and IncR replicons, showing a mosaic plasmid structure, and theblaNDM-1is harbored on a novel class I integron-like element.blaKPC-3is located on a Tn3-ΔblaTEM-1-blaKPC-3-ΔTn1722element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.03053-15

Authors: Hong Du, Liang Chen, Kalyan D. Chavda, Ruchi Pandey, Haifang Zhang, Xiaofang Xie, Yi-Wei Tang, Barry N. Kreiswirth

Institutions: Rutgers, The State University of New Jersey, Second Affiliated Hospital of Soochow University, Rutgers New Jersey Medical School, Memorial Sloan Kettering Cancer Center

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: Genomic variation in epidemic carbapenem-resistant K.pneumoniae, The molecular basis of the carbapenem resistance epidemic, G7289384428, Cancer Center Support Grant

OpenAlex ID: W2311083045

FWCI: 4.115

Cites: 22

Cited by: 55

Related to: 10