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Clofarabine ± Fludarabine with IV Busulfan and Allogeneic Stem Cell Transplantation for Advanced Myeloid Leukemia (ML) and MDS

Year: 2014
Type: article
Abstract: The nucleoside analog (NA) clofarabine (Clo) has improved antileukemic efficacy compared with fludarabine (Flu), commonly used with IV busulfan (Bu) in pretransplant conditioning. In vitro studies of [Clo+Flu] with Bu in AML cells showed higher synergistic cytotoxicity compared with [Clo+Bu] or [Flu+Bu] combination. We studied [Clo±Flu] with IV Bu in pretransplant conditioning for ML and MDS.
DOI: 10.1016/j.bbmt.2013.12.240
Authors: Diem Chu, Ben C. Valdez, Patricia S. Fox, Peter Thall, Laura Worth, Uday R. Popat, Roy B. Jones, Elizabeth J. Shpall, Chitra Hosing, Amin M. Alousi, Gabriela Rondon, Partow Kebriaei, Richard E. Champlin, Borje S. Andersson
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2312402341
FWCI:
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