Work

3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors

Year: 2014

Type: article

Abstract: 3-Amido-3-aryl-piperidines were discovered as a novel structural class of GlyT1 inhibitors. The structure-activity relationship, which was developed, led to the identification of highly potent compounds exhibiting excellent selectivity against the GlyT2 isoform, drug-like properties, and in vivo activity after oral administration.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/ml500005m

Authors: Emmanuel Pinard, Daniela Alberati, Ruben Alvarez-Sanchez, Virginie Brom, Serge Burner, Holger Fischer, Nicole Hauser, Sabine Kolczewski, Judith Lengyel, Roland Mory, Christian Saladin, Tanja Schulz-Gasch, Henri Stalder

Institution: F. Hoffmann-La Roche AG

Language: English

Topic: Amino Acid Enzymes and Metabolism

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2313079259

FWCI: 0.148

Cites: 14

Cited by: 5

Related to: 10