Comparison of Cancer Diagnoses Between the US Solid Organ Transplant Registry and Linked Central Cancer Registries
Year: 2016
Type: article
Study design: Observational Study
Abstract: US transplant centers are required to report cancers in transplant recipients to the transplant network. The accuracy and completeness of these data, collected in the Scientific Registry of Transplant Recipients (SRTR), are unknown. We compared diagnoses in the SRTR and 15 linked cancer registries for colorectal, liver, lung, breast, prostate and kidney cancers; melanoma; and non-Hodgkin lymphoma (NHL). Among 187 384 transplants, 9323 cancers were documented in the SRTR or cancer registries. Only 36.8% of cancers were in both, with 47.5% and 15.7% of cases additionally documented solely in cancer registries or the SRTR, respectively. Agreement between the SRTR and cancer registries varied (kappa = 0.28 for liver cancer and kappa = 0.52-0.66 for lung, prostate, kidney, colorectum, and breast cancers). Upon evaluation, some NHLs documented only in cancer registries were identified in the SRTR as another type of posttransplant lymphoproliferative disorder. Some SRTR-only cases were explained by miscoding (colorectal cancer instead of anal cancer, metastases as lung or liver cancers) or missed matches with cancer registries, partly due to recipients' outmigration from catchment areas. Estimated sensitivity for identifying cancer was 52.5% for the SRTR and 84.3% for cancer registries. In conclusion, SRTR cancer data are substantially incomplete, limiting their usefulness for surveillance and research.
DOI: 10.1111/ajt.13818
Institutions: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Texas Department of State Health Services, Illinois Department of Public Health, Michigan Department of Health and Human Services, University of Iowa, New Jersey Department of Health, Colorado Department of Public Health and Environment, New York State Department of Health, University of Hawaii Cancer Center, Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
Awards: Surveillance, Epidemiology and End Results (SEER) Program - Iowa, G1196668276, G1472229785, G1932976417, G2112066787, G2238803135, #14: Residual Tissue Repository to Create HIV Cancer Tumor Tissue Microrarrays , SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS (SEER) PROGRAM., G2557693156, NEW JERSEY CANCER PREVENTION & CONTROL PROGRAM, G2875564675, G2925750098, G2970228389, G311352318, G3161224617, G3205575695, G3423876156, G3485696153, G3651850380, NATIONAL CANCER PREVENTION & CONTROL PROGRAM - ILLINOIS, G3725490100, G3857949968, G391480630, WS No. 12 Patterns of Care DX Year 2008, G413360666, G4467426518, G4843834169, G49039603, NATIONAL CANCER PREVENTION AND CONTROL PROGRAM, G5132823645, CALIFORNIA'S PARTICIPATION IN THE NATIONAL CANCER PREVENTION AND CONTRO PROGRAM, G5333917095, G5760116466, G5783477249, NATIONAL CANCER PREVENTION AND CONTROL PROGRAM, G63565440, G6428689724, G6585519052, G667355291, G702041046, G7278087418, G747710681, G7772923945, G8014336463, G8054769457, G8550955980, MICHIGAN CANCER PREVENTION & CONTROL PROGRAM, G867096425, NEW YORK STATE CANCER PREVENTION & CONTROL PROGRAM, G9000141391
OpenAlex ID: W2313845242