Work

Relation between Marrow Hematopoietic Activity and Development of Bone Changes Induced in Rats by Recombinant Human Granulocyte Colony-stimulating Factor.

Year: 1997

Type: article

Abstract: We examined rats treated with a high dosage of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in order to investigate the relation between marrow hematopoietic activity and development of bone changes. Recombinant human G-CSF (1, 000, μg/kg/day) was daily given intravenously to 14-week-old rats for 28 days, and the hindlimb bones were examined histopathologically. In all types of bones, the bone marrow cellularity in the rhG-CSF-treated group was higher than that in the control group. In the rhG-CSF-treated rats, granulocytic hypercellularity was observed in the bone marrow, and the marrow cavities of several bones were fully occupied by hematopoietic cells. Bone changes characterized by accelerated osteoclastic bone resorption and osteogenesis due to intramembranous ossification were observed in the rhG-CSF-treatd rats, and these changes were found only in the bones with active hematopoietic marrow. These results suggest that the development of bone lesions induced by rhG-CSF may be closely related to the bone marrow hematopoietic activity and that the changes may take place in the bone with active hematopoietic marrow.

Source: Journal of Toxicologic Pathology

DOI: 10.1293/tox.10.115

Authors: Masami Suzuki, Kenji Adachi, Tetsuro Sugimoto, Hiroyuki Nakayama, Kunio Doi

Institutions: Chugai Pharmaceutical Co., Ltd. (Japan), The University of Tokyo

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Chugai Pharmaceutical