Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(R)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915)
Year: 2015
Type: article
Source: Journal of Medicinal Chemistry
DOI: 10.1021/jm501185j
Authors: Hidenori Takahashi, Doris Riether, Alessandra Bartolozzi, Todd Bosanac, Valentina Berger, Ralph Binetti, John Broadwater, Zhidong Chen, Rebecca Crux, Stéphane De Lombaert, Rajvee Dave, Jonathon A. Dines, Tazmeen Fadra-Khan, Adam Flegg, Michael Garrigou, Ming-Hong Hao, John Huber, J. Matthew Hutzler, Steven Kerr, Adrian Kotey, Weimin Liu, Ho Yin Lo, Pui Leng Loke, Paige E. Mahaney, Tina M. Morwick, Spencer Napier, Alan Olague, Edward Pack, Anil K. Padyana, David S. Thomson, Heather Tye, Lifen Wu, Renee M. Zindell, Asitha Abeywardane, Thomas Simpson
Institutions: Boehringer Ingelheim (United States), Evotec (United Kingdom)
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: closed
OpenAlex ID: W2313916324