Clinical trial of trimethoprim-sulfamethoxazole in the treatment of vivax, ovale and falciparum malaria.
Year: 1987
Type: article
Abstract: A compound of trimethoprim (TMP) and sulfamethoxazole (SMZ) was effective in the treatment of vivax, ovale and falciparum malaria. Two patients with vivax malaria received 16 mg TMP /80 mg SMZ /kg body weight in 3 divided doses daily for 3 days. A patient with ovale malaria received 10 mg TMP /50 mg SMZ /kg body weight in 4 divided doses daily for 4 days. These doses were followed by 15 mg primaquine daily for 2 weeks. A patient with falciparum malaria received 16 mg TMP /80 mg SMZ /kg body weight in 3 divided doses daily for 3 days. In all patients, radical cures were achieved; neither relapse nor recrudescence has occurred. Trimethoprim-sulfamethoxazole succeeded in causing rapid clearance of asexualparasites from peripheral blood of the patients and producing rapid defervescence. No symptomatic adverse reactions to TMP-SMZ were experienced.
Authors: YUKIO YOSHIDA, YOSHITSUGU MATSUMOTO, MINORU YAMADA, TSUNEZO SHIOTA, HISAO YOSHIKAWA, KAE OKABAYASHI, TATSUYA TEGOSHI, TETSUYA YOSHIKAWA, AKIO KOBAYASHI, RYUKI KIN
Institutions: Kyoto Prefectural University of Medicine, Kyoto City Hospital
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2313956224