Year: 2015
Type: conference-paper
Abstract: Normal mammalian hearing requires cochlear outer hair cell active processes that amplify the traveling wave with high gain and sharp tuning, termed cochlear amplification.We have used optical coherence tomography to study cochlear amplification within the apical turn of the mouse cochlea.We measured not only classical basilar membrane vibratory tuning curves but also vibratory responses from the rest of the tissues that compose the organ of Corti.Basilar membrane tuning was sharp in live mice and broad in dead mice, whereas other regions of the organ of Corti demonstrated phase shifts consistent with additional filtering beyond that provided by basilar membrane mechanics.We use these experimental data to support a conceptual framework of how cochlear amplification is tuned within the mouse cochlear apex.We will also study transgenic mice with targeted mutations that affect different biomechanical aspects of the organ of Corti in an effort to localize the underlying processes that produce this additional filtering.
Source: AIP conference proceedings
DOI: 10.1063/1.4939339
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2314275622