Work

Targeting and therapeutic peptides in nanomedicine for atherosclerosis

Year: 2016

Type: article

Abstract: Peptides in atherosclerosis nanomedicine provide structural, targeting, and therapeutic functionality and can assist in overcoming delivery barriers of traditional pharmaceuticals. Moreover, their inherent biocompatibility and biodegradability make them especially attractive as materials intended for use in vivo In this review, an overview of nanoparticle-associated targeting and therapeutic peptides for atherosclerosis is provided, including peptides designed for cellular targets such as endothelial cells, monocytes, and macrophages as well as for plaque components such as collagen and fibrin. An emphasis is placed on recent advances in multimodal strategies and a discussion on current challenges and barriers for clinical applicability is presented.

Source: Experimental Biology and Medicine

DOI: 10.1177/1535370216640940

Author: Eun Ji Chung

Institution: University of Southern California

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Southern California, Chicago Biomedical Consortium, National Heart, Lung, and Blood Institute