Work

Pathways Mediating Activity-Induced Enhancement of Recovery From Peripheral Nerve Injury

Year: 2015

Type: review

Abstract: In Brief This article outlines the novel hypothesis that exercise promotes axon regeneration after peripheral nerve injury through neuronal brain-derived neurotrophic factor (BDNF), and there are three required means of promoting BDNF expression: 1) increased signaling through androgen receptors, 2) increased cAMP-responsive element–binding protein expression, and 3) increased expression of the transcription factor SRY-box containing gene 11. Program design and sex determine how sex hormones, neurotrophins, and axon regeneration respond to exercise after peripheral nerve injury.

Source: Exercise and Sport Sciences Reviews

DOI: 10.1249/jes.0000000000000047

Authors: Manning J. Sabatier, Arthur W. English

Institution: Emory University

Language: English

Topic: Nerve injury and regeneration

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green