Year: 2016
Type: article
Abstract: β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.
Source: Respiratory Research
Institutions: University of Aberdeen, University of Cape Town, International Centre for Genetic Engineering and Biotechnology, Institute of Infectious Disease and Molecular Medicine, Ghent University, VIB-UGent Center for Inflammation Research, East Tennessee State University, Erasmus MC, MRC Centre for Medical Mycology
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,490
Awards: G1255693949, MRC Centre for Medical Mycology, G3230536273, Amelioration of Sepsis by Macrophage Activation, G5449486140, Training Innate Immunity: A new approach to the treatment of Sepsis, G6110814618, C-type lectins in antifungal immunity, G9000023059, Innate Immunity and Cardiovascular Function in Sepsis
OpenAlex ID: W2314813843