Work

Assessment of coronary wall thickening in autosomal dominant hyper- immunoglobin E syndrome (AD-HIES) using TRAPD-MRI

Year: 2016

Type: article

Abstract: Background Autosomal dominant hyper-IgE (AD-HIES), also called Job’s syndrome, is a rare primary immunodeficiency caused by dominant mutations in STAT3. AD-HIES is characterized by elevated levels of IgE, an ineffective immune response to several infectious agents, and connective tissue and arterial abnormalities. To date, coronary artery evaluation in AD-HIES patients has been limited to lumenography by CTA or MRA. Direct in vivo coronary vessel wall imaging may allow for earlier detection of coronary artery disease, possibly at the subclinical stage, and may lead to more accurate assessment of treatment efficacy. The goal of this prospective study was to evaluate the coronary artery walls of AD-HIES patients using MRI and compare to healthy subjects and subjects with known coronary artery disease.

Source: Journal of Cardiovascular Magnetic Resonance

DOI: 10.1186/1532-429x-18-s1-o5

Authors: Khaled Z Abd-Elmoniem, Nadine Ramos, Saami Yazdani, Steven Holland, Alexandra Freeman, Ahmed M Gharib

Institutions: National Institutes of Health, University of South Alabama

Language: English

Topic: Cardiac Imaging and Diagnostics

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000