Year: 2011
Type: conference-abstract
Abstract: Objectives The International Agency for Research on Cancer identified “occupational exposure as a painter” as a cause of lung cancer. Identifying the specific causative agent(s) has been difficult since painters are exposed to mixtures of known and suspected carcinogens that change over time. Using a large pooled dataset, we evaluated the risk of lung cancer among painters by duration of employment and painting activity. Methods Detailed individual data on smoking were available for 16258 lung cancer cases (605 painters, 3.7%) and 19922 age- and sex-matched controls (473 painters, 2.4%) from SYNERGY, a pooled effort of 12 case-control studies in Europe and Canada. Painting activity was classified from job titles using ISCO 1968 and ISIC Revision 2 codes. Multivariable logistic regression models were adjusted for age, gender, centre, smoking habits and previous employment in high-risk occupations. Results An OR of 1.38 (95% CI 1.20 to 1.59) was found for ever working as a painter; the excess risk of lung cancer increased with increasing years of employment (p-trend<0.0001). In never smokers, the OR was 1.75 (95% CI 1.01 to 3.02). The highest lung cancer risks with significant exposure-response trends were observed for construction (p-trend<0.0001), spray (p-trend=0.01) and repair painters (p-trend=0.03). Results were similar by histological type. Conclusions These findings support the evidence of an increased risk of lung cancer among painters. Analyses by painting activity may help to identify causative agents.
Authors: N. Guha, A. Olsson, H. Kromhout, R. Vermeulen, T. Bruning, B. Pesch, B. Kendzia, H.-E. Wichmann, I. Bruske, I. Stucker, S. De Matteis, M. T. Landi, N. Caporaso, J. Siemiatycki, P. Gustavsson, N. Plato, F. Merletti, D. Mirabelli, L. Richiardi, W. Ahrens, H. Pohlabeln, K.-H. Jockel, D. Zaridze, A. Cassidy, J. Lissowska, N. Szeszenia-Dabrowska, S. Benhamou, A. Slamova, L. Foretova, V. Janout, P. Rudnai, E. Fabianova, R. S. Dumitru, F. Forastiere, B. Bueno-de-Mesquita, S. Peters, P. Boffetta, V. Benhaim-Luzon, K. Straif
Institutions: Centre international de recherche sur le cancer, Utrecht University, Institute for Prevention and Occupational Medicine, Inserm, University of Milan, National Cancer Institute, Université de Montréal, Karolinska Institutet, University of Turin, Leibniz Institute for Prevention Research and Epidemiology - BIPS, University of Duisburg-Essen, Russian Cancer Research Center NN Blokhin, University of Liverpool, The Maria Sklodowska-Curie National Research Institute of Oncology, Nofer Institute of Occupational Medicine, Variabilité Génétique et Maladies Humaines, Charles University, Masaryk Memorial Cancer Institute, Palacký University Olomouc, Orszagos Kornyezetegeszsegugyi Intezet, Public Health Authority of the Slovak Republic, National Institute for Public Health and the Environment, Tisch Cancer Institute
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2315365264