Work

Steroid-Loaded Hemostatic Nanoparticles Combat Lung Injury after Blast Trauma

Year: 2015

Type: article

Abstract: In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone nanoparticles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immunohistochemistry. We found that dexamethasone-loaded hemostatic nanoparticles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.

Source: ACS Macro Letters

DOI: 10.1021/acsmacrolett.5b00061

Authors: W. Brad Hubbard, Margaret M. Lashof-Sullivan, Erin B. Lavik, Pamela J. VandeVord

Institutions: Virginia Tech, Case Western Reserve University, Salem VA Medical Center

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, NIH Office of the Director, Congressionally Directed Medical Research Programs