Work

Enantioselective Conjugate Additions of α-Amino Radicals via Cooperative Photoredox and Lewis Acid Catalysis

Year: 2015

Type: article

Abstract: We report the highly enantioselective addition of photogenerated α-amino radicals to Michael acceptors. This method features a dual-catalyst protocol that combines transition metal photoredox catalysis with chiral Lewis acid catalysis. The combination of these two powerful modes of catalysis provides an effective, general strategy to generate and control the reactivity of photogenerated reactive intermediates.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja512746q

Authors: Laura Ruiz Espelt, Iain S. McPherson, Eric M. Wiensch, Tehshik P. Yoon

Institution: University of Wisconsin–Madison

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Alfred P. Sloan Foundation, National Institute of General Medical Sciences

Award: Visible Light Photocatalysis