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Sialic Acid-dependent Self-Agglutination is a Barrier to Influenza Virosome Assembly

Year: 2016

Type: article

Abstract: Enhancing the affinity of weak interactions through multivalency and avidity is a cornerstone of many biological recognition processes. Through assembly of influenza hemagglutinin (HA) virosomes, we found that high densities of this spike protein, normally needed to bind the primary viral receptor sialyl oligosaccharide (SO), also promote self-agglutination following two-dimensional membrane presentation of HA. Sterically blocking HA-SO binding prevented this and allowed for virosome formation, predicting that the sialidases normally present in the influenza virion are important for displaying HA at high density.

Source: Matters Select

DOI: 10.19185/matters.201601000013

Authors: Ashraf Yousif, Maya Sangesland, Daniel Lingwood

Institutions: Ragon Institute of MGH, MIT and Harvard, Harvard University

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2316275405

FWCI:

Cites: 24

Cited by:

Related to: 10