Work

The validation of profluorescent nitroxides as potential probes to monitor mitochondrial oxidative stress

Year: 2016

Type: dissertation

Abstract: In cells, the balance of oxidation and reduction reactions (redox chemistry) plays a significant role in key biological processes such as cell signaling, cell fate determination and the body's defence systems, all of which contribute significantly to the overall well-being of the body. This project served as a step forward in developing a more efficient method to monitor mitochondrial redox status. The method is based on the application of profluorescent nitroxides (PFN) that change in fluorescent intensity based on changing mitochondrial redox status. A major impact of this project is to facilitate assessment of mitochondrial redox status and thereby determine the efficacy of antioxidant treatments.

Source: QUT ePrints (Queensland University of Technology)

Author: Kok Leong Chong

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: QIMR Berghofer Medical Research Institute, Australian Government

OpenAlex ID: W2316424538

Cites: 97

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Related to: 10