Validating Assisted Reproductive Technology Self-Report
Year: 2014
Type: article
Abstract: To the Editor: The use of fertility-enhancing therapies, including assisted reproductive technologies (ART), has more than doubled in the United States between 1996 and 2005.1 Approximately 1.4% of US live births and 4.3% of Massachusetts live births are conceived using ART.2 Several studies have noted an increased risk of birth defects in ART pregnancies compared with spontaneous pregnancies.3,4 Previous attempts to validate maternal self-reported ART have shown mixed results. A Danish study demonstrated sensitivity of 83% for assisted conception.5 However, maternal self-report in the Pregnancy Risk Assessment Monitoring System in the United States overestimated ART use when compared with clinic-reported data.6 We compared self-reported ART use among Massachusetts participants in the National Birth Defects Prevention Study (NBDPS) with data from ART clinics. The NBDPS is a population-based, multicenter case-control study of birth defects, with exposure information collected by maternal interview.3,7 The Society for Assisted Reproductive Technology (SART) collects ART procedure information from clinics, providing a gold standard for comparison with self-reported information. The SART database contains information from over 91% of ART clinics in the United States, with validation conducted annually.2 All Massachusetts ART clinics report to SART. SART records have been linked to vital records for Massachusetts deliveries as part of a project to evaluate ART outcomes.8 Massachusetts NBDPS participants with in-state deliveries between September 2004 and December 2008 were matched to SART records by delivery date, birth/fetal death certificate number, and birth outcome. Sensitivity and specificity were calculated to measure the accuracy of self-reported ART use among NBDPS participants compared with ART use recorded in SART. Variables compared include in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), use of donor eggs, frozen eggs or embryos (frozen cycle), and presence of multiple fetuses on ultrasound. The NBDPS did not collect ICSI information until 2006, so these analyses are restricted to 2006–2008 deliveries.TABLE: Sensitivity and Specificity of Maternal Self-Reported ART Use Among Massachusetts NBDPS Participants Compared with Clinic Data from SARTaOf 1452 Massachusetts NBDPS participants with in-state deliveries during the study period, 77 (5.3%) matched to a record in the SART database. Four NBDPS subjects who reported IVF or ICSI did not match to a SART record, possibly because of misreporting or because ART had been performed out-of-state. Among NBDPS subjects with matching SART records, specificity was 87% or greater for all procedures and outcomes examined (Table). Sensitivity was 91% for IVF use and did not differ by case-control status. Sensitivity was 100% for use of frozen cycle and presence of multiple fetuses. Sensitivity was lower for ICSI (71%) and donor egg use (67%), although the number of donor egg cycles was small. Sensitivity for ICSI use was 82% among 20 subjects interviewed at <9 months following delivery compared with 60% among 24 subjects interviewed at 9 months or more. ICSI sensitivity was 80% among 37 cases versus 50% among 7 controls (data not shown). To our knowledge, this is the first study to validate maternal ART exposure information in the NBDPS. The study’s main strength is its use of validated ART clinic data, providing a gold standard for comparison with maternal self-report. Limitations include small numbers for several ART procedures and within subgroups. Also, we could evaluate only Massachusetts residents. However, although Massachusetts residents comprise only 12% of NBDPS subjects, they account for roughly 40% of all study subjects who report a fertility procedure. Among deliveries to NBDPS subjects with matching SART records, self-reported use of IVF and several other ART procedures and outcomes demonstrated good agreement with clinic data, while use of ICSI and donor eggs were underreported. Future studies need to validate ART exposure with larger sample sizes, including subjects from other states. These results increase confidence in observed associations between ART and birth defects3 in the NBDPS. ACKNOWLEDGMENTS We acknowledge Daksha Gopal for her assistance with this project. Rebecca F. Liberman Massachusetts Department of Public Health Boston, MA [email protected] Judy E. Stern Geisel School of Medicine at Dartmouth Lebanon, NH Barbara Luke Michigan State University East Lansing, MI Jennita Reefhuis Centers for Disease Control and Prevention Atlanta, GA Marlene Anderka Massachusetts Department of Public Health Boston, MA
Source: Epidemiology
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2318780945