Year: 2012
Type: article
Abstract: Four phthalazine derivatives have been prepared from substituted 2-bromobenzaldehyde acetals by a sequence involving: (1) lithiation and formylation; (2) deprotection; and (3) condensative cyclization with hydrazine. Two additional phthalazines were prepared by a similar sequence following direct lithiation of benzaldehyde acetals substituted by anion-stabilizing groups at C3. These syntheses can be conveniently carried out to give phthalazines in overall yields of 40–70%.
Source: Heterocyclic Communications
DOI: 10.1515/hc-2012-0079
Institution: Oklahoma State University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $1,808
OpenAlex ID: W2319195249