Year: 1996
Type: article
Abstract: We are cunently producing mutants to probe the f1.mction of p 13suc I.Cyclin A is first observed late in the G 1 phase of the cell cycle.and its abundance increases throughout S and G2.It fom1s complexes with either CDK2 or CDC2.Our structure of a genetically truncated fom1 of cyclin A (residues 171-432) consists oftwo striking] y similar helical domains, despite low sequence homology.Comparison with the structure of a complex between a fragment of cyclin A and CDK2 [4] showed that in contrast to the major structural changes ofCDK2, cyclin remains essentially unaltered when complexed.Thus, cyclin acts as a template, complimentary to the basally active confom1ation of CDK2 in the complexed structure.Ow• poster will desc1ibe details of the results mentioned above.as well as the results of on-going work to fmther characte1isethese proteins.
Authors: A. D. B. Pannifer, T. R. Burke Jr, D. Barford
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2319789977