Work

Aberrant Interleukin-1 Receptors in a Cortisol-Secreting Adrenal Adenoma Causing Cushing's Syndrome

Year: 1998

Type: article

Abstract: Cortisol-secreting adrenal adenomas are an uncommon cause of Cushing's syndrome. Little is known about the events leading to the formation of these tumors, but molecular defects, including activating mutations of receptors for corticotropic factors, have been suspected in this process. Structural mutations of the corticotropin-receptor gene have not been detected in these tumors,1 but some have had gastric inhibitory polypeptide,2,3 vasopressin,4 and more recently, β-adrenergic receptors.5 In this report, we provide evidence of the involvement of immune cells and one of their cytokine products in the formation of an adrenocortical adenoma in a patient with Cushing's syndrome. A striking . . .

Source: New England Journal of Medicine

DOI: 10.1056/nejm199807023390105

Authors: Holger S. Willenberg, Constantine A. Stratakis, Christian Marx, Monika Ehrhart-Bornstein, George P. Chrousos, Stefan R. Bornstein

Institutions: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Clinical Center, Leipzig University, National Institute of Mental Health

Language: English

Topic: Adrenal and Paraganglionic Tumors

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2320050200

FWCI: 11.84

Cites: 20

Cited by: 104

Related to: 10