Year: 2014
Type: article
Abstract: Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.
Source: Nano Letters
DOI: 10.1021/nl502385k
Institutions: National Cancer Institute, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States), Baylor College of Medicine, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Seattle Pacific University, University of California, Santa Barbara
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: U.S. Department of Energy, U.S. Department of Health and Human Services, Cancer Prevention and Research Institute of Texas, Frederick National Laboratory for Cancer Research, Leidos, National Institutes of Health, U.S. Food and Drug Administration, Oak Ridge Institute for Science and Education, National Cancer Institute, National Institute of General Medical Sciences
OpenAlex ID: W2321771552