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Mp72-07 Expression of Multiplex Urine Cytokines Discriminate Functional Bladder Capacity in Interstitial Cystitis Patients

Year: 2016

Type: article

Abstract: increased urinary frequency (control 4.86Æ0.634vs. cystitis 9.0Æ0.447voids, p<0.001), and decreased average volume voided per micturition (control 0.26Æ0.036vs. cystitis 0.14Æ0.016g, p¼0.022).These changes were associated with increased splenocyte production of IL-1ß, IL-6 and TNF-a in response to TLR2/4 stimulations.Elevated expressions of IL-6, TNF-a, TLR4 and CD11b mRNAs in the lumbar spinal cords were observed in cystitis-induced mice, which was also associated with phenotypic and functional changes.CONCLUSIONS: Central and peripheral TLR activations are associated with bladder inflammation, pelvic pain and voiding dysfunction in URO-OVA mice, providing a potential mechanistic insight for human IC/BPS.

Source: The Journal of Urology

DOI: 10.1016/j.juro.2016.02.1620

Authors: Laura Lamb, Yao-Chi Chuang, Hui-Ying Liu, Bernadette Zwaans, Sarah Bartolone, Kenneth Peters, Michael Chancellor

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2321816493

FWCI:

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