Work

A road less traveled paved by IDO silencing

Year: 2013

Type: article

Abstract: Orchestrating a cytotoxic polymorphonuclear neutrophil (PMN) response strictly focused within the tumor tissue remains a formidable challenge for the successful therapeutic use of these cells. A Salmonella vector carrying an shRNA against indoleamine 2,3-dioxygenase has been shown to recruit PMNs and enhance their activation specifically in the tumor bed, resulting in significant anticancer effects.

Source: OncoImmunology

DOI: 10.4161/onci.23322

Authors: Edwin R. Manuel, Don J Diamond

Institutions: City Of Hope National Medical Center, City of Hope

Language: English

Topic: Cancer Research and Treatments

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913