Epigeneka i fi ziologija gena Epigenecs and gene physiology
Year: 2009
Type: article
Abstract: Epigenetics is focused on gene physiology, analyzing inherited variations in gene expression, while genomics is focused on gene anatomy, analyzing gene structure. DNA methylation and histone post-translational modifications are the basic epigentic mechanisms regulating gene activity. These two processes complement each other, creating an epigenetic network of events which regulates specifi c gene activity. Establishing a particular type of epigenetic network depends on the anatomy of both the gene and its promoter, as well as the permanent interaction of exogenic and endogenic factors, which result in a particular epigenetic mark. As a result of new data, the importance of epigenetic marks as a reversible process, is becoming increasingly relevant to disease development, especially for cancer. One looks forward to the promise, still to be fully realized, of research in epigenetics, including new approaches to therapy and the development of “smart” epigenetic drugs.
Institution: Ruđer Bošković Institute
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1532501644