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Infection Dynamics of Sylvatic Dengue Virus in a Natural Primate Host, the African Green Monkey

Year: 2014
Type: article
Abstract: The four serotypes of mosquito-borne dengue virus (DENV-1, -2, -3, and -4) that circulate in humans each emerged from an enzootic, sylvatic cycle in non-human primates. Herein, we present the first study of sylvatic DENV infection dynamics in a primate. Three African green monkeys were inoculated with 10(5) plaque-forming units (pfu) DENV-2 strain PM33974 from the sylvatic cycle, and one African green monkey was inoculated with 10(5) pfu DENV-2 strain New Guinea C from the human cycle. All four monkeys seroconverted (more than fourfold rise in 80% plaque reduction neutralization titer [PRNT80]) against the strain of DENV with which they were inoculated; only one (33%) of three monkeys infected with sylvatic DENV showed a neutralizing antibody response against human-endemic DENV. Virus was detected in two of three monkeys inoculated with sylvatic DENV at low titer (≤ 1.3 log10pfu/mL) and brief duration (≤ 2 days). Clinical signs included rash and elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels.
DOI: 10.4269/ajtmh.13-0492
Authors: Kathryn A. Hanley, Mathilde Guerbois, Tiffany F. Kautz, Meredith Brown, Stephen S. Whitehead, Scott C. Weaver, Nikos Vasilakis, Preston A. Marx
Language: English
Field: Medicine
Open Access status: bronze
Funders: New Mexico State University, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Research Resources, Office of Research Infrastructure Programs, National Institutes of Health
Awards: G1015710804, G2019221917, G222542617, G228809269, G3417980631, G4495922382, G5226292765, G5514357541, G620453595, G79265297, G875361481, G9000015656, G9000060349, G9000117170, G9000205260, G9000233845
OpenAlex ID: W2322315938
FWCI: 1.223
Cites: 50
Cited by: 26
Related to: 10